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PharmaESS provides true real/simulated duality—the same platform operates seamlessly in both physical execution mode controlling actual production equipment and digital twin simulation mode modeling virtual facilities.

 

Digital Twin Development Program

Graxiom maintains multiple pharmaceutical facility profiles designed to serve the diverse needs of the industry—from early-stage biotech startups requiring flexible small-batch capabilities to large-scale commercial manufacturing operations.

Advanced bioreactor and pharmaceutical equipment

Digital twin technology enables virtual commissioning of complex pharmaceutical equipment

Medium-Size CMO (Available Now)

Fully operational digital twin representing typical contract manufacturing with multi-product capabilities

High-Potency API (In Development)

Specialized containment and safety systems for high-potency active pharmaceutical ingredients

Cell & Gene Therapy (In Development)

Advanced modalities requiring specialized equipment and regulatory frameworks

Personalized Medicine (In Development)

Small-batch, patient-specific manufacturing with complete traceability

Medium-Size CMO Facility Specifications

  • 8 Production Suites
  • 12,000 m² GMP-Classified Space
  • 47 Major Process Equipment Units
  • 180+ Instruments & Sensors
  • 85 Workforce Modeled
  • 23 Active Product Processes
  • 15-20 Tech Transfers/Year Capacity
  • Grade A-D Cleanroom Classifications
     

Equipment Portfolio

  • 12 Stainless Steel Reactors (50L to 2,000L)
  • 6 Bioreactors (500L to 5,000L)
  • 8 Filtration Systems
  • 4 Chromatography Skids
  • 3 Lyophilizers
  • 5 Tablet Presses
  • 4 Filling Lines
  • 5 Autoclave/Sterilization Units

Digital Twin Capabilities

Commission and validate entire facilities virtually before breaking ground. Complete regulatory validation in simulation mode, reducing time-to-operation and eliminating costly physical commissioning errors.

Test new production recipes, process parameters, and deviation scenarios without touching physical equipment. Optimize processes in silico before committing to production runs.

Train operators on digital replicas of equipment not yet installed. Practice batch operations in realistic GMP environment, reducing training time and improving operator readiness.

Full audit trails, electronic signatures, and ALCOA+ data integrity in digital twin mode. Regulatory activities begin in simulation, accelerating validation timelines.

Virtually manufacture potential products to evaluate capacity constraints, identify equipment bottlenecks, and estimate production costs before commitment. De-risk new product introductions.

Accept and validate client products in digital twin, compressing traditional 6-12 month timelines to weeks. Virtual validation eliminates the need for multiple physical trial runs.



 

Ready to Transform Your Manufacturing?

Discover how PharmaESS can streamline your operations, accelerate technology transfer, and eliminate vendor lock-in with true plug-and-play architecture.

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